Chromatography, Magnetic Resonance & Mass Spectrometry
Provides the exact mass of the analyzed sample and therefore access to the sum formula
The LC-NMR/MS setup was first introduced by Bruker BioSpin in 1999. An LC-NMR system including a Bruker Peak Sampling Unit (BPSU-36) was coupled with a Bruker Daltonics esquire series ion trap mass spectrometer via a Bruker NMR-MS interface (BNMI). Nowadays mostly maXis / micrOTOF time-of-flight mass spectrometers are used in hyphenated systems.