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antibodies / for breast cancer / progesterone / immunohistochemistry
antibodies
Novocastra PA0312

Antigen Background The human progesterone receptor (PR) is expressed as two isoforms, PRA (94 kD) and PRB (114 kD), which function as ligand-activated transcription factors. These two isoforms are transcribed from distinct estrogen receptor ...

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Leica Biosystems
breast cancer reagents / antibodies / immunohistochemistry
breast cancer reagents
Novocastra Cytokeratin 5

Antigen Background Cytokeratins are a large family of cytoskeletal proteins found in epithelial cells. They are coordinately synthesized in pairs so that at least one member of each family is expressed in each epithelial cell. Cytokeratins ...

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Leica Biosystems
breast cancer reagents / for tissue cultures / monoclonal antibodies / for antigens
breast cancer reagents
Novocastra Cytokeratin 7

Cytokeratins are intermediate filament proteins present in epithelial cells. They are expressed in a tissue-specific manner in normal organs and the tumors that arise from them. Cytokeratin 7 belongs to the neutral basic type B subfamily ...

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Leica Biosystems
breast cancer reagents / pathology / monoclonal antibodies / for antigens
breast cancer reagents
Novocastra Cytokeratin 14

Antigen Background Cytokeratins 14 and 5 are useful to distinguish stratified epithelial cell types from simple epithelial cell types. Cytokeratin 14 has been reported to be expressed in neoplasms of squamous cell origin. Product Specific ...

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Leica Biosystems
breast cancer reagents / for tissue cultures / pathology / monoclonal antibodies
breast cancer reagents
Novocastra Cytokeratin 20

Cytokeratin 20 has been demonstrated to be almost entirely confined to the gastric and intestinal epithelium, urothelium and Merkel cells of the skin. Cytokeratin 20 is less acidic than other type I cytokeratins and is of interest due ...

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Leica Biosystems
breast cancer reagents / monoclonal antibodies / for antigens / tissue
breast cancer reagents
Novocastra E-Cadherin

E-cadherin is a Ca2+-dependent, transmembrane cell adhesion molecule. It plays an important role in the growth, development and the intercellular adhesion of epithelial cells. Most tumors have an abnormal architecture and any subsequent ...

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Leica Biosystems
breast cancer reagents / monoclonal antibodies / for antigens / tissue
breast cancer reagents
Novocastra Estrogen Receptor

... antibodies to ER has allowed the determination of receptor status of breast tumors to be carried out in routine histopathology laboratories.

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Leica Biosystems
breast cancer reagents / monoclonal antibodies / for antigens / tissue
breast cancer reagents
Novocastra Fluid Protein-15

Gross cystic disease of the breast is a benign premenopausal disorder in which cysts are a predominant pathological lesion. These cysts appear to be formed from excessive apocrine cystic secretions. This fluid is composed of several glycoproteins ...

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Leica Biosystems
tissue culture reagents / pathology / for breast cancer / monoclonal antibodies
tissue culture reagents
Novocastra Ki67

The Ki67 antigen is a nuclear protein which is expressed in all active parts of the cell cycle (G1, S, G2 and mitosis) but is absent in resting cells (G0). In contrast to many other cell cycle-associated proteins, the Ki67 antigen is ...

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Leica Biosystems
breast cancer reagents / monoclonal antibodies / for antigens / cell
breast cancer reagents
Novocastra Multi-Cytokeratin (AE1,AE3)

Keratins are a family of water insoluble proteins of 40 to 70 kD. These proteins form tonofilaments, a class of intermediate filament, in epidermis as well as in almost all other epithelia. The process of normal epidermal differentiation ...

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Leica Biosystems
breast cancer reagents / monoclonal antibodies / for antigens / cell
breast cancer reagents
Novocastra p53 Protein

This monoclonal antibody recognizes both wild type and mutant forms of human p53 protein under denaturing and non-denaturing conditions. The epitope recognized by clone DO-7 can be destroyed by prolonged fixation in buffered formalin. ...

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Leica Biosystems
breast cancer reagents / monoclonal antibodies / for antigens / cell
breast cancer reagents
Novocastra p63

Antigen Background p63 is a type II integral membrane protein predominantly localized in the rough endoplasmic reticulum. p63 is reported to be expressed in a number of normal tissues including proliferating cells of the epithelium, ...

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Leica Biosystems
monoclonal antibodies / for tissue cultures / pathology / laboratory
monoclonal antibodies
Novocastra SMA

Antigen Background Cytoplasmic actins are part of the microfilament system of cytoskeletal proteins.Smooth muscle actin is found in vascular walls, intestinal muscularis mucosae and muscularis propria and in the stroma of various tissues. It ...

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Leica Biosystems
monoclonal antibodies / for tissue cultures / pathology / laboratory
monoclonal antibodies
Novocastra Vimentin

Eukaryotic cells contain a number of types of cytoplasmic filamentous proteins, microtubule, microfilaments and intermediate-sized filaments (IF). Vimentin, a 57 kD protein that is an intermediate filament is reported to be expressed ...

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Leica Biosystems
dermatopathology reagents / monoclonal antibodies / for antigens / blood
dermatopathology reagents
Novocastra CD3

The CD3 molecule consists of five different polypeptide chains with molecular weights ranging from 16 to 28 kD. The CD3 antigen is first detected in early thymocytes and its appearance probably represents one of the earliest signs of ...

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Leica Biosystems