DNA polymerase reagent SP2024
dNTP solutionfor PCR

DNA polymerase reagent
DNA polymerase reagent
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DNA polymerase, dNTP solution
for PCR


Optimase® Polymerase is a thermostable DNA polymerase with an efficient 3′ to 5′ proof-reading exonuclease activity developed for unprecedented PCR performance in single nucleotide polymorphism (SNP) and mutation discovery studies. Initially developed for denaturing high performance liquid chromatography (DHPLC) research1-4, Optimase® Polymerase is the enzyme of choice for other applications requiring high fidelity PCR amplification. Applications • SNP and mutation discovery and scoring with various techniques such as SURVEYOR® Nuclease genome scanning, DHPLC, SSCP, DGGE and others • High fidelity cloning Features High fidelity proofreading polymerase. It has a 3’-5’ exonuclease activity. Enhanced Optimase® Polymerase Buffer System Free online support and access to the automated Optimase® ProtocolWriter™ for PCR protocol design and Optimase® MasterMix Calculator™ found at www.MutationDiscovery.com™ Benefits Offers superior PCR fidelity over other proofreading polymerases1-3. Enhances the life of the DNASep® Cartridge in DHPLC experiments; does not interfere with other downstream applications, and increases amplification robustness and fidelity Enables simple and automated generation of PCR protocols; thus minimizing PCR optimization. References Muhr, D., Wagner, T. and Oefner, P. 2002. Polymerase chain reaction fidelity and denaturing high-performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci, 782:105-110. Abstract Library Entry. Nickerson, M. 2003. “Influence of PCR on DHPLC Polymorphism Characterization.” In Hecker, K. (Editor): Genetic Variance Detection: The Nuts&Bolts of DHPLC in Genomics. 2003, DNA Press.


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