Research test kit 17-HISHU-SUP-E01

allergyfor histamineclinical

Supplementary kit for 96 determinations of histamine release. This kit must be used in combination with the Histamine ELISA (17-HISHU-E01). For Research Use Only. Not for Use in Diagnostic Procedures. Specifications Regulatory Status Research Use Only. Not for Use in Diagnostic Procedures. Product Distribution Available Worldwide Sizes 96 Tests Inc Time Overnight No Inc Time See Protocol No Sample Size 30 Sample Size 2 150 Additional Information In humans, histamine (ß-imidazole ethylamine) is the most important mediator and is mostly found in the initial phase of an anaphylactic reaction ("immediate type" allergy). Histamine is produced by the enzymatic decarboxylation of histidine. In the organism, histamine is present in nearly all tissues, and it is mainly stored in the metachromatic granules of mast cells and the basophilic leukocytes. It is present in an inactive bound form and is released only as required. Histamine acts predominantly on smooth muscle and blood vessels. In humans, it is responsible for the broncho-constriction occurring during the acute phase. In the vessels, its constrictive effect is limited to the venula, whereas arterioles are dilated. Furthermore, histamine causes a contraction of the cells of the vascular endothelium and increases the vascular permeability, thereby allowing higher-molecular substances to escape into the tissue. Like several other mediators, histamine does not exclusively mediate various clinical symptoms of anaphylaxis but also induces a series of effects which are directed towards a termination of the anaphylactic reaction.