Flow controller nanomake™-L

laboratoryoperationalautomated

Product Overview
nanomake™-L is India’s first automated microfluidic platform for precise and reproducible nanoformulation at laboratory scale. It supports both single-use and reusable microfluidic chips to enable reproducible scale-up of formulations such as mRNA-lipid nanoparticles (LNPs), polymeric nanoparticles, liposomes and emulsions while preserving critical quality attributes. The instrument uses controlled microfluidic mixing technology to produce uniform and reproducible nanoparticles.

Key Differentiators

• Cost-effective and locally manufactured: 40–60% lower acquisition cost than imported systems, with reduced maintenance costs due to local components and support.
• Fully automated, plug-and-play operation: zero manual intervention; automates priming, in-line dilution, flow rates and mixing ratios.
• Multi-use microfluidic chips: reusable and customizable chips with different internal volumes and construction materials.
• Patented microchannel design: proprietary architecture for precise mixing and consistent nanoformulation.
• Broad flow rate compatibility: operates from 100 µL/min to 50 mL/min for lab-scale experiments and scale-up studies.
• Integrated wash program: built-in cleaning routine to enable chip reuse and reduce cross-contamination and operational costs.
• Scalability and flexibility: compatible with multiple syringe sizes (500 µL–10 mL) and a range of nanomaterials including LNPs, polymeric nanoparticles, liposomes and emulsions.

Why nanomake™-L?

• Intuitive user interface and straightforward operation
• Reproducible formulation results
• Facilitates nanoformulation optimization workflows
• Flexible operation modes and chip configurations
• Support for multi-use microfluidic chips

Features

• Fully automated operation
• Multi-use microfluidic chip
• Wide flow rate range on a single platform
• Configurable three precursor pumps
• Built-in washing program
• Interchangeable microfluidic chips
• Replaceable sample collection attachments: 2 mL, 15 mL and 50 mL

Specifications

• Flow rates: 100 µL/min to 50 mL/min
• Temperature range: ambient to 60°C (optional pre-heater)
• Number of precursor pumps: 3
• Syringe sizes supported: 500 µL, 1 mL, 2.5 mL, 5 mL, 10 mL
• Microreactor: reusable multi-use microfluidic chip (interchangeable)
• Nanomaterial synthesis: lipid nanoparticles (LNPs), polymeric nanoparticles, liposomes, emulsions, microspheres
• Controls: total flow rate, flow ratio, sample volume, in-line dilution