Hollow-fiber filter BioOptimal™ MF-SL

for liquidslaboratorypolysulfone

BioOptimal MF-SL is a hollow fiber microfilter that utilizes an efficient filtration mechanism based on size exclusion and tangential flow filtration. These two aspects allow the filter to smoothly and effectively separate the contents of a solution. Applications Process simplification BioOptimal MF-SL is able to clarify solutions quickly and completely in a single processing step. Therefore, it simplifies the cell culture clarification process and makes it more cost-effective by eliminating the needs for large investments like centrifuges and expensive disposable items like other depth filters. Features & Performances Key Features ・ Low TMP (Trans Membrane Pressure) ・ High flux, short filtration time ・ High protein permeability & recovery rate ・ Very low permeate turbidity, less bioburden ・ Low pressure stress at filtration process TFF-Perfusion cell culture evaluations Monoclonal Antibody (mAb) is one of the main focus categories in biopharmaceuticals. There are several types of cell culture systems such as fed-batch and perfusion culture. Although conventional batch systems are widely accepted in the current process, perfusion based cell culture systems offer the potential to greatly increase cell density and productivity for a long term periods. It is widely accepted that hollow fiber works as a cell separation device in perfusion culture. We conducted to evaluate the performance of perfusion cell culture in TFF (Tangential Flow Filtration) system.