Synthetic bone substitute DeepActive™

for orthopedic surgerymalleablepowder

Product Overview
DeepActive™ Synthetic Bone Graft is a 100% synthetic bone substitute indicated for filling and augmentation of bone defects that do not compromise structural stability. Clinical data including multicenter trials and regulatory registration report robust bone integration; registry data (NMPA) indicate a 24‑week graft fusion rate of 100%. The product can be hydrated with the patient's autologous blood or normal saline and is supplied in multiple forms (cylinders, powders, rectangles, granules) to suit surgical requirements.

Key Features

• Free of growth factors: 100% synthetic material without rhBMP‑2, rhBMP‑7, rhPDGF‑BB or other added growth factors, reducing risks related to ectopic bone formation or postoperative inflammation.
• Hierarchical micro‑nano structuring: Three‑dimensional interconnected porosity that promotes osteoinduction, osseointegration, vascular ingrowth and cell proliferation.
• Multiple forms and intraoperative shaping: Available as cylinders, powders, rectangles and granules; can be cut and shaped to clinical requirements.
• Long shelf life: Stable at room temperature with a 4‑year shelf life.
• Biocompatibility: Non‑immunogenic, non‑allogeneic, non‑exudative.

Indications

• Repair and filling of bone defects resulting from trauma or surgery where structural stability of the bone is not compromised.
• Suitable for cases without contraindications to bone grafting; intended for a wide range of defect types and anatomical locations.

Regulatory status and clinical evidence

• Registered with China NMPA (official registration data: 24‑week graft fusion rate 100%).
• Regulatory approvals in multiple countries including Belarus and Indonesia.
• Selected as a national clinical application demonstration product; clinical use reported in 3000+ major hospitals across 31 Chinese provinces/municipalities and in Belt & Road partner countries.

Characteristics / Technical specifications

• Composition: 100% synthetic bone graft material (no added growth factors).
• Porosity: 3D interconnected micro‑nano porosity to enhance osteoinduction, osseointegration and vascular regeneration.
• Forms available: Cylinders, powders, rectangles, granules (multiple formats for clinical application).
• Hydration: Can be hydrated with autologous blood or normal saline prior to implantation.
• Shelf life: 4 years at room temperature.
• Biocompatibility: Non‑immunogenic, non‑allogeneic, non‑exudative.
• Handling: Can be cut and shaped intraoperatively to meet clinical requirements.
• Indications: Bone void filling and augmentation for defects from trauma or surgery.