Synthetic bone substitute DeepActive™

for orthopedic surgerygranulesrigid

Product Overview
DeepActive™ Synthetic Bone Graft is a high-activity synthetic bone graft material mainly made of hydroxyapatite with excellent biocompatibility, compressive strength, and three-dimensional interconnected porosity structure (up to 70% porosity) facilitating osseointegration and bone regeneration. According to the China NMPA registration data, the product can achieve 100% bone graft fusion rate at 24 weeks after implantation.

Key Features

• Free of growth factors: 100% synthetic material without rhBMP‑2, rhBMP‑7, rhPDGF‑BB or other added growth factors, reducing risks related to ectopic bone formation or postoperative inflammation.
• Hierarchical micro‑nano structuring: Three‑dimensional interconnected porosity that promotes osteoinduction, osseointegration, vascular ingrowth and cell proliferation.
• Multiple forms and intraoperative shaping: Available as cylinders, powders, rectangles and granules; can be cut and shaped to clinical requirements.
• Long shelf life: Stable at room temperature with a 4‑year shelf life.
• Non‑immunogenic, non‑allogeneic, non‑exudative.

Indications

• Repair and filling of bone defects resulting from trauma or surgery where structural stability of the bone is not compromised.
• Suitable for cases without contraindications to bone grafting; intended for a wide range of defect types and anatomical locations.

Regulatory status and clinical evidence

• Registered with China NMPA (official registration data: 24‑week graft fusion rate 100%).
• Regulatory approvals in multiple countries including Belarus, Indonesia and Thailand, and registration in EU and other 10+ countries (in progress)
• Selected as the only Biomedical Materials for National Key Special Project on Application Demonstration; clinical use reported in 3000+ major hospitals across 31 Chinese provinces/municipalities and in Belt & Road partner countries.

Characteristics / Technical specifications

• Composition: Hydroxyapatite and Silicon.
• Porosity: 3D interconnected micro‑nano porosity (up to 70%) to enhance osteoinduction, osseointegration and vascular regeneration.
• Forms available: Cylinders, powders, rectangles, granules (multiple forms for clinical application).
• Hydration: Can be hydrated with autologous blood or normal saline prior to implantation.
• Shelf life: 4 years at room temperature.
• Biocompatibility: Non‑immunogenic, non‑allogeneic, non‑exudative.
• Handling: Can be cut and shaped intraoperatively to meet clinical requirements.
• Indications: Bone void filling and augmentation for defects from trauma or surgery.