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Nerve tissue matrix axoguard ®
xenograft

nerve tissue matrix
nerve tissue matrix
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Characteristics

Applications
nerve
Material
xenograft

Description

Axoguard Nerve Connector is a semi-translucent coaptation aid designed for Connector-Assisted Repair® (CAR) of a transected nerve with a gap up to 5 mm. connector solutions Connector-Assisted Repair alleviates tension and suture-related inflammation at the critical zone of regeneration. Connector-Assisted Repair provides an alternative to direct repair that reduces the potential for axonal escape and aiding alignment of nerve ends. Axoguard® porcine small intestine submucosa (SIS) vascularizes and remodels into the patient’s own tissue, creating a physical barrier to surrounding soft tissue.5 Intra-operative versatility aids in reinforcing the coaptation site of direct, graft or cable graft repairs. the importance of biomaterials In a pre-clinical study conducted to evaluate host tissue response, porcine small intestine submucosa (SIS, Axoguard Nerve Connector) performed significantly better than cross-linked bovine collagen type I (CLC, Integra NeuraGen®) in all outcomes and categories. Specifically, the study provided evidence that SIS had increased levels of M2 (pro-healing) macrophages which are indicative of a remodeling response, while CLC had increased levels of M1 (pro-inflammatory) macrophages indicative of a chronic inflammatory response indications INDICATIONS FOR USE: Axoguard Nerve Connector is indicated for the repair of peripheral nerve discontinuities where gap closure can be achieved by flexion of the extremity. The device is supplied sterile and is intended for one-time use. CONTRAINDICATIONS: This device is derived from porcine source and should not be used for patients with known sensitivity to porcine material.

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