TOF-MS spectrometer timsTOF Pro

for proteomicsbenchtop

The timsTOF Pro with PASEF® technology delivers revolutionary improvements in scan speed, with enhanced specificity and high sensitivity Omics in 4D TIMS adds 4th dimension of separation Speed With Parallel Accumulation Serial Fragmentation (PASEF) technology >100 Hz sequencing speed can be achieved. High throughput Extremely high data acquisition speed increases the throughput of biological experiments significantly. Depth Due to the sensitivity gains from PASEF, more peptides and their post-translational modifications (PTMs) can be identified. Robustness The unique instrument design with orthogonal reflection into TIMS enables routine operation over thousands of samples without instrument cleaning. The new standard for 4D-Proteomics™ - Dig deeper and faster into the proteome Mass spectrometry (MS)-based proteomics has become a powerful technology for the identification and quantification of thousands of proteins. However, the coverage of complete proteomes is still very challenging due to the limited speed, sensitivity and resolution of current mass spectrometers. The timsTOF Pro uses the Parallel Accumulation Serial Fragmentation (PASEF®) acquisition method to provide extremely high speed and sensitivity to reach new depths in shotgun proteomics and phosphoproteomics, using low sample amounts. Dual TIMS Trapped Ion Mobility Spectrometry (TIMS) is first and foremost a separation technique in gas phase, which resolves sample complexity with an added dimension of separation in addition to HPLC and mass spectrometry, increasing peak capacity and confidence in compound characterization.