Automatic sample preparation system FLEX SWILE NMR

automatedroboticfor LC/MS

Overview
The FLEX SWILE workflow automates NMR and/or LC‑MS sample preparation to replace manual, time‑consuming and error‑prone steps. SWILE technology enables automated one‑to‑one gravimetric "pick & decision dispense" of solid compounds directly from source vials using Chemspeed's overhead gravimetric dispensing tool together with an on‑deck analytical balance. Disposable glass tips (SWINs) eliminate cross‑contamination; SWINs come in multiple diameters and are adjustable to the target amount. A tilt/shake rack loosens powders prior to pick‑up.

Key features

• Gravimetric decision dispensing for high accuracy and precision
• Solid dispensing range: hundreds of μg to ~5 mg (±10 μg resolution with on‑deck balance)
• No cross‑contamination (disposable glass SWINs)
• No dead volume; fully inert glass path
• Unattended operation for high throughput

Workflow (FLEX SWILE NMR)
The typical automated sequence includes:

• Optional barcode read of source vial
• Transport source vial to tilt/shake rack
• Loosen powder by tilt/shake
• Gravimetric pick & decision dispense into NMR tube and/or LC vial
• Return source vial to rack
• Add solvent
• Stir/tumble/shake to dissolve
• Perform offline or online NMR and/or LC‑MS analysis (GMP‑compatible)

Benefits

• Proprietary robotic tool‑exchange interface (Chemspeed)
• Ventilated hood option for safe, conditioned atmosphere
• Compact optimized footprint (~90×90 cm) for high capacity and reduced facility cost
• Modular: combine SWILE Robotic Tool with on‑deck balance, tilt/shake rack, barcode reader, multigripper and other tools
• Automated dispensing into NMR tubes and LC vials; optional on‑deck balance for ±10 μg resolution
• Gravimetric and/or volumetric liquid handling; compatible with tumble stirrers or shaking modules
• AUTOSUITE software: drag & drop experiment design, Python device support, LIMS/ELN integration and autosampler formats

Technical specifications

• Technology: SWILE gravimetric "pick & decision dispense" using overhead gravimetric dispenser and secondary on‑deck analytical balance
• Solid dispensing range: hundreds of μg to ~5 mg
• Resolution/precision: approx. ±10 μg with on‑deck balance
• Disposable glass tips (SWINs): multiple diameters, adjustable for target amount
• Anti‑cross‑contamination: disposable tips; fully inert glass path
• Pre‑treatment: tilt/shake rack for powder loosening
• Liquid handling: gravimetric and/or volumetric dissolution; compatible with tumble stirrer or shaking modules
• Sample outputs: NMR tubes and LC vials; supports online and offline NMR/LC‑MS
• Footprint: optimized footprint approx. 90 x 90 cm (3 x 3 ft)
• Environment: ventilated hood available; suitable for GMP environments
• Software & integration: AUTOSUITE for automation; integrations with LIMS/ELN and common autosampler workflows