High-throughput synthesis platform FLEX ISYNTH

microwaverobotized

Overview
Chemspeed's fully automated, modular FLEX ISYNTH enables automated, parallel library synthesis and lead-optimization workflows for medicinal chemistry. The system integrates reaction setup, multistep synthesis, work-up, purification, analysis and automated product transfer to storage within configurable parallel μL–mL workflows.

Key capabilities

• Expands chemical space exploration to accelerate reaction, reagent and molecule screening for drug discovery.
• Modular ISYNTH deck supports conventional, microwave-assisted, photochemistry and reactive gas workflows, among others.
• End-to-end automation covering reaction setup, multistep synthesis, work-up, purification, analysis and transfer to storage vials for solid- and liquid-phase libraries and reaction screening.
• Configurable parallel throughput (examples: 24 / 48 / 96 ... reactions per run).
• Integrated sampling and analytics: benchtop online NMR, HPLC (MS), UPLC (MS), GC (MS), UV‑VIS, NIR/MIR and DLS measurement cells.
• Gravimetric solid handling from μg to g and gravimetric/volumetric liquid handling from μL to mL, with chemistry-proven features (pH control, filtration, heated needle extension).
• Proprietary robotic tool exchange to automate diverse tasks.
• Ventilated hood for conditioned and safe operation.
• AUTOSUITE software for drag & drop experiment design, execution and integration with LIMS, ELN and AI/ML closed-loop workflows.

Workflow components / typical process steps

• Inertization
• Gravimetric solid dispensing
• Volumetric liquid dispensing
• Heating with shaking (mixing)
• Sampling (direct injection or into LC vial)
• Work-up (filtration, liquid/liquid extraction, SPE)
• Product transfer and sample collection

Benefits

• Fully automated, integrated reaction preparation, synthesis, work-up, analysis and output to storage vials for solid- and liquid-phase library synthesis and reaction screening.
• Disposable, multi-functional high-precision glass reactor arrays covering μL–mL reaction scales.
• Glass reactor arrays with screwless self-sealing, shaking (up to ~1,700 rpm), heating (up to 150°C), cooling (down to −20°C), reflux, vacuum, inertization, evaporation, L/L extraction, filtration, SPE, crystallization and drying.
• Wide dynamic-range gravimetric and volumetric handling for solids and liquids.
• Integrated analytics and automated sampling for high-throughput screening and data-rich outputs.
• Software orchestration for scalable experiment design and laboratory integration (AUTOSUITE, ARKSUITE).

Applications

• Medicinal chemistry library synthesis and lead optimization
• High-throughput reaction screening and method development
• Parallel microL–mL scale synthesis for discovery and early development

Technical specifications

• Model name: FLEX ISYNTH
• Reaction scales: from μL to mL
• Parallel throughput: configurable platforms supporting 24 / 48 / 96 ... parallel reactions per run
• Reactor arrays: disposable high-precision glass arrays, screwless self-sealing
• Mixing: shaking up to ~1,700 rpm
• Temperature control: heating up to 150°C, cooling down to −20°C
• Capabilities: reflux, vacuum, inertization, evaporation, L/L extraction, filtration, SPE, crystallization, drying
• Solid handling: gravimetric from μg to g
• Liquid handling: gravimetric from mg to g and volumetric from μL to mL
• Integrated analytics: benchtop online NMR, HPLC (MS), UPLC (MS), GC (MS), UV‑VIS, NIR/MIR, DLS measurement cell
• Safety: ventilated hood for conditioned operation
• Software: AUTOSUITE for drag & drop experiment design, integration with LIMS/ELN and AI/ML closed-loop workflows; ARKSUITE for lab orchestration and workflow management