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Vascular tissue matrix PhotoFix®

vascular tissue matrix
vascular tissue matrix
vascular tissue matrix
vascular tissue matrix
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vascular, cardiac


Glutaraldehyde Fixation vs. Photo-Fixation Unlike glutaraldehyde treated tissue, PhotoFix tissue uses dye-mediated photo-oxidation to crosslink and stabilize the internal collagen structure - eliminating toxic by-products that create sites where calcium can bind to tissue.1-4 PhotoFix is nonimmunogenic, biocompatible, non-cytotoxic, and maintains natural physical properties and biomechanical integrity Use of PhotoFix in Congenital Cardiac Surgery at Boston Children's Hospital6 490 patches used between 2008 and 2011 in 364 patients (median age 5.3 years). Mean late follow-up of 3.2±1.6 years. Demonstrated excellent performance in cardiovascular repair in children. Wide range of applications show consistent handling characteristics and biocompatibility. Eight patch specimens were available for histological analysis (up to 72 months): “Inflammation was absent or minimal in 6 cases and mild in 2 others.” “No calcification noted in 5 cases, mild calcification in 2 cases and at least moderate calcification in 1 case. Review of clinical and pathology database of patches used in cardiac surgery at one children's hospital noted:7 PhotoFix used in locations exposed to lower stresses showed little or no calcification. Calcification did not differ significantly between PhotoFix and autologous pericardium in multiple intracardiac applications. The grades of neointima formation did not demonstrate a significant difference between PhotoFix and autologous pericardium. Vascular repair and reconstruction Carotid Iliac Femoral Tibial blood vessels Arteriovenous access revisions Intracardiac repair Great vessel repair Suture line buttressing Pericardial closure



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