Reactor loading system DIT® OEB5

CSV Containment provides three DIT® reactor charging stations with double chamber for a new department for HPAPI production. DIT® reactor charging with double chamber for HPAPI production is the safest way to charge drums, even of different diameters, without changing any part of the equipment. The DIT® dual-chamber configuration allows for a unidirectional handling flow of drums and powders, from clean to dirty. This causes the charging chamber to be segregated from the pre-chamber and drum, which is never exposed to potential contaminants. A very high level of containment is thus achieved, up to OEB6. For this reason, a newly built Facility in northern Italy has chosen CSV Containment to realize no less than three double-chamber, double-iris rigid isolators. Although these are twin stations, each one is dedicated to a specific reactor, taking into account all the constraints around the charging point, its size, as well as its orientation. Three glove boxes with automatic irises and pre-chamber drum inlets have been placed in the state-of-the-art pharmaceutical manufacturing plant. Each station has been designed to facilitate the work of the operators as much as possible. Indeed, their design is meant to provide convenient access to the chambers for reactor charging and offer adequate space during bag-out operations. In addition, bag handling inside the isolator is designed to be unhindered, thanks to the inflatable seal that allows the metal profile usually used around the inner door to be eliminated. In this way, the floor of the two chambers is clear of clutter and bags can be conveniently moved without having to overcome obstacles.