D-dimers are fission products of fibrin and play an important role in blood coagulation. Elevated D-dimer levels are found in patients with confirmed deep venous thrombosis (DVT), pulmonary embolism (PE), disseminated intravascular coagulation (DIC) and trauma. The levels rise during pregnancy and considerably high levels are associated with possible complications.
D-dimer concentration by itself does not imply anything, which gives it a non-specific character. Nevertheless, if D-dimer concentration is not elevated, pulmonary embolism can be ruled out as a possible complication with high probability.