Cortisol is a glucocorticoid hormone that affects the metabolism of carbohydrates, proteins, and fats. Chronic, excessive glucocorticoid release leads to hyperadrenocorticism (HAC).
Pituitary-dependent hyperadrenocorticism (PDH), more commonly known as Cushing‘s disease, is caused by a pituitary tumour (mostly adenomas) in the brain. The tumour triggers excessive levels of adrenocorticotropic hormone (ACTH), which stimulates the adrenal glands near the kidneys to produce cortisol. A small percentage of dogs with HAC have a tumour of one of the adrenal glands. This form of HAC is called adrenal-dependent HAC and results from a direct increase in cortisol production by the adrenal gland tumour.
The overproduction of cortisol causes symptoms such as hair loss, pot-bellied appearance, increased appetite, and polydipsia and polyuria. Addison’s disease (hypoadrenocorticism, or underproduction of cortisol) occurs less commonly than the Cushing’s disease in dogs.
This is a homogenous, immunoturbidimetric test.
A sample of 40 µl serum is needed.
The test duration is under 8 minutes.
0.8 – 24.0 µg/dl