The CA125 monoclonal antibodies recognize epitopes in the protein core of the CA125 antigen. These monoclonal antibodies show high specificity for ovarian cancer, and can be used for development of fast and sensitive homologous or heterologous assays.
According to ISOBM TD1-workshop CA125 contains three antigenic domains:
A-domain (Oc125)
B-domain (M11)
C-domain (Ov197)