Cancer test kit HERIGUARD™ MMR

oncologyfor genetic testingblood

Hereditary cancers account for ~5% of all malignancies and occur because of an inherited deleterious gene alteration from one of the parents. People carrying such alterations have a high risk of developing cancer at an early age, as well as developing multiple synchronous or metachronous cancers. Genetic screening of high-risk populations, such as individuals with a family history of cancer, is important in identifying cancer-related germline genetic variants and the chance of developing cancer in your lifetime, prompting early discovery of cancer lesions and improving patient survival. Identifies inherited predisposition to gastrointestinal (GI) cancer  Heriguard™ MMR reports germline genetic alterations in 24 genes, including mismatch repair (MMR) genes – a class of genes responsible for correcting mismatch errors that arise during DNA replication. The panel evaluates the hereditary risk of GI cancer while providing genetic evidence for diagnosing a series of hereditary cancer syndromes including hereditary non-polyposis colon cancer (HNPCC, also known as Lynch syndrome), MUTYH-associated polyposis, hereditary pancreatic cancer and hereditary gastric cancer among others. WHO IS IT FOR Individuals with 10+ adenomatous polyps or 2+ hamartomatous polyps  Individuals with one or more family members that have familial adenomatous polyposis (FAP)  Individuals with one or more family members that have colorectal or endometrial cancer before the age of 50  Individuals with two or more family members that has GI cancers at any age  Individuals with family members diagnosed with tumor susceptibility syndrome or related tumors