Blood flow imaging system LS series

laser speckle contrast

Introduction
LS Series laser speckle blood flow imager is a non-contact imaging system for real-time, full-field monitoring of microcirculatory blood flow. Using Laser Speckle Contrast Imaging (LSCI) principles, the system captures laser-illuminated tissue images with CCD/CMOS sensors and processes speckle contrast to provide two-dimensional maps of relative blood flow. It is designed for preclinical and clinical research in neuroscience, pharmacology and cardiovascular fields, enabling time-resolved observation of tissue hemodynamics across a wide field of view.

Features

• High spatial definition: 2048×1536 display resolution enabling micron-level visualization of microvascular flow distribution and relative changes in flow values.
• Wide-field and zoom adaptability: configurable field of view suitable for both small-animal experiments and clinical surface perfusion studies in humans.
• Continuous acquisition: sustained recording at user-defined frame rates; typical single-file output approx. 7 MB for efficient long-duration capture.
• Flexible ROI/TOI analysis: select regions of interest (ROI) and time of interest (TOI); save selections and perform online or offline quantitative averaging of flow metrics.

Product Composition
System components include laser illumination module, CCD/CMOS acquisition camera, mounting and positioning accessories, and analysis software. Detailed component layout and options are shown on the product page.

Application field

• Neuroscience: monitoring cerebral blood flow in stroke models (MCAO), ischemia/reperfusion studies and neurovascular research.
• Pharmacology & cardiovascular research: assessment of drug effects on microcirculation and perfusion dynamics.
• Gastrointestinal research: mesenteric vessel imaging for studies of acute mesenteric ischemia and intestinal perfusion.
• Peripheral and cranial microcirculation: facial nerve electrophysiology, burn depth assessment, lower-limb blood flow measurement and spinal cord injury models.
• Complementary therapies research: investigation of mechanisms in acupuncture, moxibustion and other interventions affecting microvascular perfusion.

Technical specifications

• Imaging principle: Laser Speckle Flow Imaging (LSFI) based on LSCI; speckle contrast analysis for visualization of relative blood flow distribution.
• Temporal resolution: millisecond-level acquisition for near real-time monitoring.
• Spatial resolution: micron-level spatial detail (dependent on optics and working distance).
• Display resolution: 2048×1536 (ultra-HD).
• Recording: continuous recording at configured frame rates; single output file ~7 MB (typical).
• ROI/TOI: flexible selection of spatial and temporal intervals; supports online and offline quantitative analysis of ROI averages.
• Acquisition hardware: CCD or CMOS camera for laser-illuminated area capture.
• Operation mode: non-contact imaging; no exogenous contrast agents required.
• Applicable subjects: from small animals (mice, rats) to large animals (pigs, dogs) and human surface perfusion studies.