Pilot freeze dryer HDG-70Z10-50

for productionfor the pharmaceutical industrylow-output

Pilot Freeze Dryer is a pilot-scale lyophilizer designed for small-batch production and pilot runs to stabilize heat-sensitive and bioactive materials while reducing transportation and storage costs and inactivation risk. Freeze-drying preserves bioactivity by allowing reconstituted materials to recover near their pre-freeze-dried conformation and function.

Key benefits

• Stabilizes high-temperature-sensitive drugs and bioactive materials for storage at 0–4°C or ambient temperature after lyophilization.
• Reduces transport and storage cost and lowers inactivation risk compared with liquid cold-chain distribution.

Product features

• Suitable for small-batch production & pilot run: Shelf total size 0.54㎡; capacity circa 2,046 penicillin bottles Ø16 mm.
• Excellent temperature uniformity control: ±0.5°C shelf temperature accuracy; ±1°C uniformity across all shelves.
• Superb cooling performance: Rapid cold-trap pull-down from +20°C to −45°C in about 30 minutes; ultimate temperatures down to −70°C; simultaneous cabinet and cold-trap cooling to reduce wait times and improve efficiency.
• Sample safety: Emergency protection functions provided as standard.
• Complete compliance documentation: CE, FDA 21 CFR Part 11, GMP, SAT, 3Q.
• Control and automation: PC–PLC dual-layer control architecture with Siemens PLC for equipment monitoring, execution of control chains and an available PC operation interface.
• Mechanical and process systems included:
  • Cascade dual refrigeration system with Tecumseh compressors.
  • Hydraulic system for shelf lifting and stopper operation (hydraulic station, plate cylinder, etc.).
  • Vacuum system: rotary vane vacuum pump, electric evacuation valve, stainless-steel piping, vacuum probe and PID leak-control valve for precise vacuum regulation.
  • Circulating system: circulating pump, heater, plate heat exchanger and expansion box transferring heat/cold via silicone oil to shelf layers/products.

Process capabilities / Q&A highlights

• Filling equipment: available.
• Gradient/multi-stage temperature control: supported and programmable; process design support available from Haier Biomedical technical team.
• Batch capacities (examples): Penicillin Ø12 mm ≈ 3,690 pcs; Ø16 mm ≈ 2,046 pcs; Ø22 mm ≈ 1,056 pcs.
• Drying end-point judgment: optional function.
• Eutectic point monitoring: supported; eutectic point detection device available.

Technical specifications

• Model: HDG-70Z10-50
• Cold trap temperature: −85°C
• Ice condenser capacity: 10 kg
• Power supply: 220 V / 50 Hz
• Weight: 800 kg
• Exterior dimensions (W × D × H): 890 × 1660 × 1940 mm
• Shelf dimension: 300 × 450 mm
• Shelf total area: 0.54 m²