Manual sample preparation system XTRX500

automaticlaboratorymixing

Accurate and repeatable sample preparation is essential to determining content uniformity in pharmaceutical products. “To ensure the consistency of dosage units, each unit in a batch should have a drug substance content within a narrow range around the label claim.” USP Uniformity of Dosage Units. Traditional methods of sample extraction are often tedious and time-consuming, especially with problematic drug formulations that may take many hours to dissolve. Teledyne Hanson’s new Sample Preparation Extractor (XTRX500) provides an advanced, efficient solution for rapid extraction through an innovative, proprietary combination of high frequency pulverization and forced jet mixing in a compact, programmable platform. As samples are prepared within chemically compatible, single-use recyclable pouches, XTRX500 eliminates many of the problems associated with handling glassware, manual crushing, dry material measurement and transfer, cleaning validation, and the reproducibility errors inherent in manual sample-prep methods. The rapid and reproducible extraction process of the XTRX500 is made possible by its powerful crushing mechanism combined with forced-jet mixing, single-use pouches, and a programmable interface. Powerful crushing. High frequency pulsing in the crushing mechanism rapidly reduces whole solids to fine powders, greatly accelerating the release of API from the dosage form. Rapid mixing. Reciprocating rollers on the mixing bar generate high turnover of fluids inside the pouch for faster dissolution and a homogeneous mixture.