In addition to requiring precise control of dissolution media temperatures, the United States Pharmacopeia (USP) and Food and Drug Administration (FDA) Guidance for Industry state that, if dissolved gases in dissolution medium affect the dissolution results of products then the medium must be degassed. Media preparation is typically a time-consuming and labor-intensive task in the dissolution laboratory. Heating and dissolution media preparation required temperature, deaeration (removal of dissolved gases), and precise volumetric dispensing into flasks requires diligence, patience and care. Automated methods can streamline these tasks while freeing the chemist for more productive analytical work. Automation carries the added benefit of providing instrument validation while eliminating human error. The Hanson Media-Mate Plus system was designed and engineered specifically to meet these requirements. A large pre-heat tank controls media temperature, while its exclusive deaeration-dispense assembly removes dissolved gases and accurately dispenses precise adjusted media volumes into groups of 6 or 7 dissolution flasks simultaneously – all in less than five minutes. The Media-Mate Plus uses a self-tuning PID controller and a Teflon heater to heat the media. Media is moved by low pressure or vacuum and directed by a two-position, multi-channel pinch valve. The media is deaerated by a thin film vacuum process. The media volume is accurately measured by a user-set incremental measuring system. The system may be easily moved throughout the laboratory, servicing several dissolution baths.