Coagulation rapid test ADIM-8025

proteinD-dimerthrombin

The HUBI D-Dimer is a rapid, point of care test based on immunochromatography assay to be used with the HUBI-QUANpro for the quantitative détermination of cross-linked fibrin dégradation products (D-Dimers) in citrate or EDTA anticoagulated whole blood or plasma specimens. Fibrinogen is a main protein of the blood coagulation system. During the coagulation process, thrombin converts fibrinogen to soluble fibrin by the proteolytic removal of both fibrinopeptide A and B. The fibrin clot is then digested by plasmin and fibrin dégradation products with différent molecular weights are released into the bloodstream. D-dimer is a final product of fibrin dégradation (MW 180 kDa). It consists of the remnants of ail three chains that are cross linked by disulfide bonds. The dimeric structure is held by two isopeptide bonds between the C-terminal parts of g-chains forming a cross-linked région. Elevated levels of D-dimer were found in the blood of patients with pulmonary thromboembolism, deep vein thrombosis (DVT), atherosclerosis and other cardiovascular diseases.