Automatic sample preparation system MAGELIA

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Overview
MAGELIA is an open, benchtop automation platform built for complex molecular biology workflows including NGS library preparation. It miniaturizes reactions from the µL to sub‑µL range using confined‑reaction and magnetic bead handling technologies to improve consistency and throughput. Runs are walk‑away: load samples and reagents, start the protocol, and recover libraries ready for QC or sequencing the next morning.

Key proposition

• Walk‑away automation for library preparation
• Micro‑volume efficiency compatible with low‑input workflows
• Protocol‑agnostic, open to commercial kits and chemistries

Features

• High performance with low‑input or challenging samples through miniaturized, confined reactions that improve molecule recovery and reduce failure rates.
• Compact benchtop footprint designed to fit standard laboratory benches without external infrastructure.
• Connected instrument with WiFi and Ethernet support for updates, notifications, and protocol download.
• True overnight walk‑away operation enabling load‑in‑evening and library recovery the next day.
• Integrated modules for heating, cooling, thermal cycling and magnetic handling to run complex protocols end‑to‑end.
• Open architecture to run validated commercial kits or custom chemistries to avoid vendor lock‑in.

Functionalities

• Purification
• Elution
• Heating
• Cooling
• Mixing
• Merging
• Capture (magnetic bead handling)
• Amplification
• Labelling

Performance highlights

• PCR‑free WGS libraries from 5 ng DNA (validated workflows) — reported performance ~50× below typical kit lower limits.
• RNA‑seq libraries generated from inputs down to 1 ng total RNA (validated on real workflows).

Operational benefits

• Maximise data from limited material: improved molecule recovery reduces failures on scarce samples.
• Operational efficiency: overnight walk‑away runs reduce hands‑on time and dependency on scarce expert operators; workflows can be operational in days.
• Cleaner data: reduced background and fewer adapter dimers support higher usable sequencing depth and improved transcriptome resolution.

Designed for

• Core facilities running multiple protocols and unpredictable sample types.
• Clinical and translational labs requiring robustness, traceability and low‑input performance.
• R&D teams validating new workflows without extensive liquid‑handler scripting.

Technical specifications

• Form factor: compact benchtop automation platform.
• Architecture: open, protocol‑agnostic system compatible with commercial kits and chemistries.
• Reaction volumes: miniaturizes reactions from µL down to sub‑µL using confined‑reaction technology.
• Liquid handling: magnetic bead handling for bead‑based cleanups and size selection.
• Thermal capabilities: integrated heating, cooling and thermal cycling.
• Connectivity: WiFi and Ethernet for updates, notifications and protocol download.
• Workflow mode: true overnight walk‑away automation; load‑and‑run operation.
• Validated performance: PCR‑free WGS from 5 ng DNA; RNA‑seq from 1 ng total RNA (per validated workflows).