Bovine pericardium dural substitute DuraGen® Plus

DuraGen® Plus Dural Regeneration Matrix is an enhanced onlay dural graft with improved porosity and strength. Overview Enhanced Porosity and Strength DuraGen Plus Dural Regeneration Matrix is one of the safest and most effective onlay grafts for the restoration and repair of dura mater. DuraGen Plus is made from a controlled collagen source with enhanced porosity and strength and is treated with a proprietary process designed to remove antigenic components, yielding our Ultra Pure Collagen™. How DuraGen Plus Works The highly porous collagen scaffold promotes rapid fibrin clot formation. DuraGen Plus rapidly provides watertight closure to prevent cerebrospinal fluid (CSF) leakage while promoting natural dural growth Features Scientifically Proven Excellent Conformability and Adherence. The hydrated graft conforms intimately to the complex surfaces of the exposed brain or spinal cord. Matrix rapidly fills with the patient's blood and plasma exudate. Rapid CSF Leak Prevention Type 1 collagen matrix rapidly initiates platelet aggregation. The fibrin clot creates a watertight barrier and binds the implanted matrix to the patient's dura. Fibroblast Migration and Tissue Formation Ultra Pure Collagen, in combination with the open pore structures, promotes fibroblast activity and acts as a scaffold for cells to deposit new collagen. Fibroblasts begin to migrate into the matrix 2 to 3 days after implantation and start laying down new collagen. Within two weeks of implantation, a neodural membrane has formed between the dural margins to permanently close the dural defect. After 6-8 weeks, the implant is resorbed and replaced by dura.