LC chromatography system SMB

for the pharmaceutical industrypilot

To extract high-purity pharmaceutical active ingredients from natural products at high yields is a major challenge. This also applies to the cannabinoid sector. Simulated Moving Bed (SMB) chromatography, as a continuous LC method, sets the standard for productivity, purity and yield. This AZURA SMB pilot system is dedicated for the continuous production of API´s. The System allows the continuous separation of mixtures of substances and extraction into two fractions. High purities and simultaneous yields of up to 100% distinguish this process from conventional preparative LC methods. The system features four preparative Pump 2.1L and seven multi-position valves integrated into four AZURA Assistans ASM 2.2L The three system pumps are equipped with 500 ml/min stainless steel pump heads, enabling volume flows of up to 250 ml/min inside the SMB cycle. The feed pump works with a 100 ml pump head and can thus also precisely dose the feed in the low flow range. The seven multi-position valves, operated by the valve unifier VU 4.1, are made of stainless steel and are equipped with connections for 1/8" pipes. The Valve Unifier VU 4.1, integrated in the ASM 2.2L provides the newest technology to our SMB systems. The smart valve drive features automatic valve recognition and adjusts torque and switching speed specifically for each valve. This RFID technology enables to read GLP data, for example the maintenance of the rotor seal exchange is simplified by automatic notifications. The new plug-in design of the ASM 2.2L allows the modules to be removed by loosening just four screws, enabling the user to quickly exchange the modules.