PSS SUPREMA gel is a universally applicable column material. It is strongly recommended for the use of aqueous eluents, also in combination with organic solvents like methanol or acetonitrile. The chemical modification of this gel permits its use with a variety of organic mobile phases. The universal application of PSS SUPREMA gel to wide range of polymer types is obtained using a well-balanced ratio of hydrophilic and hydrophobic segments in the polymer network. PSS SUPREMA columns provide the ability to determine the molecular weights of a wide range of polymers including polyacrylic acid, polymethacrylic acid, polysaccharide, cellulose, polyvinyl alcohol, hydrophilic and hydrophilic/hydrophobic block copolymers, polycations, polyanions and also proteins and other biomolecules.