Automatic sample preparation system ThermoBrite

for histologyfor cytologyFISH

Overview
Automate ISH/FISH staining to keep molecular testing in-house, reduce send-out costs and turnaround time, and free skilled staff from manual, repetitive tasks. The ThermoBrite Elite open platform supports programmable workflows and integrates with probe and detection solutions for diagnostic and research laboratories.

Products & Solutions

• Kreatech FISH Probes — Proprietary REPEAT‑FREE subtractive hybridization removes dispersed repetitive genomic elements to improve signal-to-noise for DNA FISH assays.
• Novocastra ISH Probes — Probe solutions designed to detect RNA sequences reliably when used with appropriate detection systems and ancillary reagents.
• ThermoBrite / ThermoBrite Elite — Instruments that reduce hands-on steps for FISH slide preparation; ThermoBrite Elite offers an open, programmable platform compatible with most probe types and protocols.
• BOND IHC/ISH Systems — Fully automated systems configurable for diagnostic or discovery workflows, engineered for speed, reliability and accuracy.

Educational Resources

• Steps to Better ISH — Practical guide with tips for improved ISH technique and avoidance of common errors.
• Immunohistochemistry: An Overview + Steps to Better IHC Staining
• Special Stain Techniques for the Evaluation of Mucins
• The H&E Stain – A Lesson on Consistency and Reproducibility

Technical specifications

• Automated ISH/FISH staining to reduce manual, delicate, and repetitive tasks
• Enables in-house molecular testing to shorten turnaround time and lower send-out costs
• Kreatech REPEAT‑FREE subtractive hybridization removes dispersed repetitive genomic elements for improved signal-to-noise
• Probe solutions for reliable RNA detection when used with appropriate detection systems and ancillary reagents
• ThermoBrite Elite: open programmable platform, up to 12 slides per run, support for up to 100 user-defined protocols, selectable up to 10 input reagents and 3 distinct waste lines
• BOND systems: fully automated, configurable for diagnostic and research workflows
• Hybridization efficiency typically >98% when validated on FFPE samples