Implantable neurostimulator AspireSR™

for vagus nerve stimulation

AspireSR™ detects and responds to rapid increases in heart rate, which may be associated with a seizure1 In clinical trials, over 60% of seizures treated ended during automatic stimulation. The closer the stimulation to seizure onset, the shorter the seizure duration2 VNS Therapy™ controls seizures in 3 ways Preventative Normal Mode Helps prevent seizures by delivering treatment at regular intervals all day, every day1 Responsive* AutoStim Mode Helps stop or shorten a seizure by responding to a rapid increase in heart rate, a potential seizure biomarker1,3,4 *Only available in models 106, 1000, and 1000-D On-Demand Magnet Mode Helps stop or shorten a seizure once it starts by passing the included VNS Therapy® Magnet over the generator1 Responsive VNS Therapy™ (AutoStim Mode) provides improvements in seizures control Mean follow-up 13 months p<0.001 59% reported ≥ 50% reduction in seizures 41% reported ≥ 80% reduction in seizures Responsive VNS Therapy™ devices include Normal Mode, Magnet Mode, and AutoStim Mode. Conventional VNS Therapy devices include Normal Mode and Magnet Mode. AspireSR™ is shown to improve quality of life2 Clinically meaningful and statistically significant improvements in overall QOL were seen at 3 months and continued to improve over time. AspireSR™ - Advancing the treatment of drug-resistant epilepsy Provides the proven efficacy and safety of VNS Therapy Detects and responds to ictal tachycardia in an effort to stop seizures spreading in the brain May terminate seizures by delivering automatic stimulation when a seizure occurs May reduce seizure duration and seizure severity and improve post-ictal recovery Improves quality of life