Pain management radiofrequency generator XERF™

thermal ablationthermocoagulation2-channel

Overview
XERF™ Structural Skin Tightening is a multifrequency monopolar radiofrequency system designed to deliver controlled thermal energy to shallow, middle and deep skin layers for soft tissue coagulation and collagen remodeling without numbing, needles or downtime. The system is described for dermatologic and general surgical procedures for electrocoagulation and hemostasis and is intended to provide skin tightening effects via targeted soft-tissue coagulation.

Key benefits

• No numbing, no needles, no downtime.
• Delivers energy deeper into the skin than conventional RF treatments to target structural layers responsible for lift and tightening.
• Fully customizable treatments with multiple depth and intensity settings to adapt to each patient’s skin profile.
• Shorter room time compared with treatments requiring anesthesia.

How it works
XERF™ combines two operating frequencies (6.78 MHz and 2 MHz) in a multifrequency monopolar RF approach to deposit energy at multiple tissue depths. The system uses Wave Fit™ pulse delivery and Advanced Integrated Cryogen Delivery cooling to control energy deposition while maintaining surface temperature, enabling a Never-Numb™ treatment experience. Accurate Impedance Feedback provides real-time analysis of tissue impedance to adapt delivery parameters.

Technology & treatment customization

• Multifrequency monopolar RF: combined 6.78 MHz and 2 MHz operation for deeper and targeted energy deposition.
• Wave Fit™ pulse technology to shape and time energy delivery.
• Advanced Integrated Cryogen Delivery cooling to maintain surface temperature during treatment.
• Accurate Impedance Feedback for real-time skin/tissue analysis and adaptive delivery.
• Three depth settings and ten intensity levels for personalized protocols.

Clinical evidence and findings

• In vivo studies (porcine model and clinical/histological analyses) reported internal tissue temperatures of approximately 50°C, 60°C and 70°C measured using ultrasound-guided fiber‑optic thermography.
• Histological analyses show collagen remodeling with thickening and tightening of collagen bundles at multiple depths and upward traction in fascia.
• Clinical/histological data indicate XERF™ energy can reach the SMAS (Superficial Musculoaponeurotic System), a structural layer implicated in lifting and reduction of jowl appearance.

Intended use / regulatory context
Content presented reflects distribution information for the US market: the device is described as intended for dermatologic and general surgical procedures for electrocoagulation and hemostasis. References to “skin tightening” describe tightening effects achieved via soft tissue coagulation.

Technical specifications

• Commercial name / model: XERF™
• Technology: Multifrequency monopolar radiofrequency (6.78 MHz and 2 MHz)
• Pulse technology: Wave Fit™
• Cooling: Advanced Integrated Cryogen Delivery
• Patient comfort feature: Never-Numb™ treatment (no topical numbing required)
• Feedback: Accurate Impedance Feedback (real-time tissue analysis)
• Depth settings: 3 depth settings
• Intensity levels: 10 intensity levels
• Measured internal treatment temperatures reported in studies: ~50°C, ~60°C, ~70°C
• Tissue target: up to SMAS (Superficial Musculoaponeurotic System) per histological analysis
• Intended procedures: dermatologic and general surgical procedures for electrocoagulation and hemostasis