Medical sealer Immiseal™

Immiseal™ Dural Sealant System

An absorbable synthetic sealant, applied as an adjunct to duraplasty repair such as suturing or onlay of autologous dura or non-autologous dural substitute.

The application of the Immiseal™ could prevent CSF leakage from incisions and provides a barrier to minimize dural adhesion with minimum swelling.

Immiseal™ is composed of synthetic materials. Upon mixing these materials with water, electrophilic and nucleophilic reactions would occur, leading to the formation of a hydrogel.

Key points

• Lower swelling ratio, reduces mass effects thus compression of brain tissue.
• Degradation within 21 days, meets the clinical need of cranial closure and prevents long-term mass effect to promote tissue regeneration.
• Quick gel-forming within seconds, enabling rapid sealing.
• CSF leakage prevention, with strong tissue sealing to provide a mechanical CSF barrier.
• Complete degradation: MRI in a canine brain model demonstrated implanted material visible at days 4, 7 and 14 and mostly invisible by day 21.
• Easy surgical handling: simple device, easy to assemble.