Rapid infectious disease test FASTest® C. perfringens

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FASTest® C. perfringens Toxin is a rapid immunochromatographic test for the qualitative detection of Clostridium perfringens enterotoxin in the feces of the dog, cat, goat and sheep lamb, calf, foal and piglet. The gram positive anaerobic bacterium Clostridium perfringens belongs to the physiological intestinal flora of many mammals and is facultative pathogenic. Inconvenient endogeneous (other basic diseases, diarrhoea pathogens, antibiotic therapies with massive reduction of intestinal flora etc.) and exogeneous (farming conditions, extreme changes of the food, stress etc.) factors can lead to an increased pathogenicity of C. perfringens. Next to its ability to form extremely infectious and stable spores, the formation of lethal toxins is crucial for its pathogenicity. The classification into the various types (A–E) is only due to the toxin formation. These toxins can cause extremely variable (mild to lethal progression forms) failures of the intestinal water and electrolyte balance in the different species like goat, sheep (e. g. dysenteria of lambs: type B; pulpy kidney disease: type D), cattle (haemorrhagic enteritis: type A–E), foal (haemorrhagic necrotising enteritis: type A & C) and piglet (e. g. serous-catarrhal enteritis: type A, necrotising enteritis: type C). In the dog, especially serotype A occurs, producing 2 main toxins (toxin Alpha [α] and a Clostridia enterotoxin [CPE]), rarer serotype B (toxin Beta [β]). Both C. perfringens and its CPE can be detected also in healthy dog’s feces. The CPE can be detected more often in dogs with diarrhoea compared to healthy dogs.