Microscope slide scanner Zenit fast

with barcode readerautomaticbright field

Overview
Zenit fast is the A. Menarini Diagnostics automated system for acquisition, analysis and storage of IFA slides. It standardizes and accelerates IFA workflows for clinical laboratories by combining rapid whole-well scanning, autofocus imaging, and dedicated analysis algorithms for ANA/ANCA/nDNA and tissue substrates.

Main features and benefits

• Fast screening of negative and positive samples to prioritize laboratory workflow
• Slide scanning speed: < 30 s/well for HEp-2 at 20x; < 2.5 min/well for tissues at 20x
• Support for multirun sessions to process large batches
• 8-slide tray for parallel processing
• High-quality sensor with LED microscope illumination and whole-well autofocus
• Virtual microscope for detailed navigation and operator review
• Reduced operating time per sample and optimized throughput

Powerful and reliable information management
Software is organized into three modules: Scanning, Validation and Archive. Scanning accepts worklists and runs automatic or manual scans. Validation provides digitized image navigation with a virtual microscope, customizable multiview layouts, interpretation tools and direct LIS/HIS transfer upon validation. Archive enables patient and test retrieval with free-text search and advanced queries.

Automated image analysis
Automatic classification of positive/negative results (Zenit ANA HEp-2). Quantitative fluorescence intensity measures for positives and pattern recognition on identified results, including mitosis detection. Supports ANCA ethanol/formalin classification, nDNA positive/negative discrimination and DNA Crithidia interpretation.

Detected pattern recognition (high level)

• Zenit ANA HEp-2: AC-0 (Negative), AC-1 (Nuclear homogeneous), AC-2/4/5/29 (Speckled), AC-3 (Centromere), AC-6/7 (Nuclear dots), AC-8/9/10 (Nucleolar), AC-15/16/17/18/19/20/22/23 (Cytoplasmic), AC-21 (Cytoplasmic reticular AMA)
• Zenit ANCA: Negative, c-ANCA, p-ANCA, Others

Software galleries and additional features
Dedicated mitosis galleries and relocalization tools. Built-in atlas with reference images and ICAP nomenclature. Customizable validation multiviews and full-screen virtual microscope navigation for operator review.

Technical specifications

• Magnification: 4x, 20x (optional up to 40x with extra objectives)
• Scanning speed: < 30 s/well for ANA HEp-2 at 20x; < 2.5 min/well for tissue slides at 20x
• Resolution at 20x: 0.5 μm
• Scanning mode: single or multiple runs per session (multirun supported)
• Compression: JPEG-2000; typical file size ANA/ANCA/nDNA: 5–10 MB/well; tissues: 100–150 MB/well
• 2D Data Matrix reader: yes
• Connectivity: bidirectional, HL7 protocol
• Supported substrates: HEp-2, ANCA, nDNA, tissues
• Automated analysis: ANA HEp-2 pattern recognition (8 pattern groups), ANCA classification, nDNA detection, mitosis recognition
• Electrical: AC 100–240 V 50/60 Hz; consumption 45 VA
• Mechanical: Scanner H 50 cm × W 60 cm × L 40 cm, weight 30 kg; Processing unit H 46 cm × W 52 cm × L 21 cm, weight 15 kg; Display 24” (1920×1200), adjustable height