Anti-IL-17A antibodies, mouse
Clone: TC11-18H10 | Dilution: 1:50
Order no: 130-123-799
For research use only
Size: 30 µg in 200 µL (1)
Replaces: 130-103-027, 130-102-298
The Anti-IL-17A antibodies are designed for intracellular staining of IL-17A–producing cells.
Interleukin 17 (IL-17) is a family of cytokines that play a central role in adaptive immunity as well as autoinflammatory disorders.
1 Data from several mouse models suggest that IL-17 plays a key role in the host defense against certain extracellular bacterial infections.
Recently, a new mouse T helper cell subset has been identified, which is dinstinct from Th1 and Th2 cells: IL-17–producing CD4
+ T helper (Th17) cells. Th17 cells preferentially produce IL-17A, IL-17F, IL-21, and IL-22. Receptors for IL-17 and IL-22 are expressed on various epithelial tissues, thus Th17 cells are crucial for the cross-talk between immune system and tissues.
2 It is now established that Th17 cells are responsible for driving autoimmune inflammation.
After stimulation of mouse T cells, IL-17 is not only secreted by CD4
+ T cells, but also by CD8
+ T cells and γδ T cells.
Detailed product information
Isotype: rat IgG1κ
Isotype control: Rat IgG1 – isotype control antibodies
Alternative names of antigen: CTLA-8, IL-17
Entrez Gene ID: 16171
Molecular mass of antigen [kDa]: 15
Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
Fixation: The antibody is suited for staining of formaldehyde-fixed cells.