Research reagent kit 130-123-799

research reagent kit
research reagent kit
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Anti-IL-17A antibodies, mouse Clone: TC11-18H10 | Dilution: 1:50 Order no: 130-123-799 Anti-IL-17A-APC, mouse For research use only Size: 30 µg in 200 µL (1) Replaces: 130-103-027, 130-102-298 Product overview The Anti-IL-17A antibodies are designed for intracellular staining of IL-17A–producing cells. Interleukin 17 (IL-17) is a family of cytokines that play a central role in adaptive immunity as well as autoinflammatory disorders. 1 Data from several mouse models suggest that IL-17 plays a key role in the host defense against certain extracellular bacterial infections. Recently, a new mouse T helper cell subset has been identified, which is dinstinct from Th1 and Th2 cells: IL-17–producing CD4 + T helper (Th17) cells. Th17 cells preferentially produce IL-17A, IL-17F, IL-21, and IL-22. Receptors for IL-17 and IL-22 are expressed on various epithelial tissues, thus Th17 cells are crucial for the cross-talk between immune system and tissues. 2 It is now established that Th17 cells are responsible for driving autoimmune inflammation. After stimulation of mouse T cells, IL-17 is not only secreted by CD4 + T cells, but also by CD8 + T cells and γδ T cells. Alternative names CTLA-8, IL-17 Detailed product information Technical specifications Antigen: IL-17A Clone: TC11-18H10 Isotype: rat IgG1κ Isotype control: Rat IgG1 – isotype control antibodies Alternative names of antigen: CTLA-8, IL-17 Entrez Gene ID: 16171 Molecular mass of antigen [kDa]: 15 Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide. Fixation: The antibody is suited for staining of formaldehyde-fixed cells.


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