HLA-B57 gene test kit HLA B5701 Strip
for DNA

HLA-B57 gene test kit
HLA-B57 gene test kit
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Characteristics

Tested parameter
for HLA-B57 gene
Sample type
for DNA

Description

The HLA B5701 Strip test allows the determination of the HLA B5701 alleles. Since the introduction of combined antiretroviral therapy, HIV infection has gone from being a serious and fatal disease to one which is chronic but controllable. Antiretroviral therapy usually entails combining 2 nucleosides which are analogous to reverse transcriptase inhibitors and either an HIV protease inhibitor or a non-nucleoside reverse transcriptase inhibitor. These drugs are very effective but they are associated with a series of undesired effects, such as severe hypersensitivity reactions, especially in the case of therapies using abacavir or nevirapine.Abacavir is used in the treatment of HIV-1 infection since 1999. The WHO recommends abacavir as a second-line treatment, owing to the risk of hypersensitivity associated with its use, which affects 5-8 % of Caucasian patients.Several studies have demonstrated the existence of a strong predictive correlation, in Caucasian populations and groups of Hispanic ethnicity, between hypersensitivity to abacavir and the presence of the HLA-B5701 allele. This correlation is strong enough to enable us to predict the risk of hypersensitivity to abacavir and classify individuals as low (70 %) risk, based on the absence or presence of the HLA-B5701 allele.

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