in-vitro microelectrode array system
The in vitro scratch assay is a straightforward and economical method of studying cell migration. By creating a gap on a confluent cell monolayer, the cells on the edge of the gap will move to close the “scratch”. However, existing methodologies lack consistency: abruptly moving apparatus can disturb the cell monolayers. And for HTS experiments where thousands of well plates must be scratched consistently the preparation of assays can create a real bottleneck.
The WoundScratcher was designed, developed and manufactured by Peira in close cooperation with researchers. The uniqueness of the instrument lies in the smooth and consistent two-dimensional movement produced by a rotating drive system. No abrupt or uncontrolled movements disturb the process.
Turning the wheel on the instrument results in a controlled tooth-shaped movement of the well plate carrying the samples. Each single turn of the wheel creates a gap in each of the eight wells (as opposed to four turns in conventional tools).
As a first step towards automation and standardisation of in vitro scratch experiments the WoundScratcher enhances productivity and improves quality through uniformity and consistency of the scratch.