The Peira Rotating or Translating animal cage system is a multichannel, multipurpose sample collection and drug delivery platform for freely moving small laboratory animals on which several sampling and/or infusion devices can be used simultaneously. Those devices are fixed to a rigid support frame. The animal’s home cage sits on a powered turntable, also to prevent having to bring the animal into a novel testing environment thus further reducing stress. Rotation of the tether when the animal turns, is detected by optoelectronic switches, which cause the turntable to turn in the opposite direction taken by the animal. Fluid or electrical swivels are entirely eliminated; the animal experiences almost zero torque or weight on the tether. As the swivel normally limits the number of fluid or electrical connections in traditional systems, eliminating the swivel removes this constraint. Multiple probes, electrodes and blood lines can now be placed in alert, freely moving animals to sample several physiological systems simultaneously.