laboratory dosage system
The Peira PrillDrop is a custom-made prilling equipment to conduct formulation experiments on laboratory scale. After melting the fatty acid and heating the melt to 90 respectively 100 ° C, the active molecule is added to the melt under stirring. Droplet formation starts after complete dissolution of the drug in the molten matrix (e.g. stearic or behenic acid). By applying air pressure to, the mixture is fed toward the thermostated nozzle equipped with a valve and a needle. Drop time and air pressure are set in function of the targeted formulation in order to have consistent and uniform droplet formulation.
After droplet formation at needle end, the ‘prills’ are quench cooled in liquid nitrogen in order to obtain solid spherical particles.