Portable patient monitor PeriFlux 6000 EPOS

blood flowoxygenphysiological

In the PeriFlux 6000 EPOS system, laser Doppler flowmetry (LDF) and diffuse reflectance spectroscopy (DRS) have been successfully integrated, enabling accurate measurements of blood flow and oxygen saturation in the microcirculation. This enables unexplored possibilities to study and understand complex disease progressions such as severe diabetes and other physiological events involving blood flow and oxygenation. The principal advantage of this novel technology is that it presents blood perfusion in absolute units, not only qualitatively as when using a standard laser Doppler. Furthermore, it distinguishes different speeds within the blood flow—speed-resolved perfusion. For example, it enables the ability to differentiate slow nutritive flow, essential for all living cells in the body, from faster flow that only has the purpose of transportation. In addition, it is possible to study the correlation between flow speed and red blood cell (RBC) oxygen saturation, revealing information about oxygen delivery and uptake into the surrounding tissue. To estimate the microcirculatory parameters, a unique model-based analysis of multimodal measurements is employed. The multilayered tissue model is adapted to the measured signals in real time and the following parameters are obtained from the adapted model: RBC oxygen saturation (%) RBC tissue fraction: gram RBC / 100 gram tissue (%) Oxygenized and reduced hemoglobin tissue concentration (µM) Speed-resolved perfusion: gram RBC / 100 gram tissue × mm/seconds (% RBC × mm/second). Three different speed regions: 10 mm/second Measurement depth (mm)