Magnetic transcranial magnetic stimulator Blossom² TMS

TMS + rTMS

Overview
Blossom² TMS — The AI-Ready Platform for Advanced Neuroscience Research. Designed for discovery, engineered for innovation and built for the future of programming neuroplasticity. Available for Research Use Only (RUO); investigational and not approved or cleared for clinical use.

Capabilities

• AI-ready architecture for integration with AI algorithms, external sensors, and multimodal neuromodulation workflows.
• Neuroplasticity research support: adaptive, programmable stimulation paradigms to explore and shape long-lasting neuroplastic changes.
• Adaptive timing & patterns: precise control over timing, frequency and stimulation patterns.
• Fingerprint TMS™: stimulation tailored to individual brain I-wave timing (individualized neurophysiological signatures).
• Closed-loop TMS: designed for real-time feedback and closed-loop stimulation strategies.
• Ultra-fast stimulation: advanced burst capabilities with burst frequencies up to 1000 Hz for QPS protocols.
• Custom protocols: create and save user-defined protocols with full flexibility.

Supported pulse patterns

• Single pulse (mapping and basic neurophysiology)
• Paired pulse (two pulses at defined intervals to study cortical excitability)
• rTMS (repetitive pulses at fixed frequency for cortical modulation)
• Theta Burst (TBS) — e.g., iTBS, cTBS, imTBS
• Alpha Burst (10 Hz) for targeted neuromodulation
• Beta Burst (20 Hz) to investigate beta-band neurodynamics
• QPS (quadri-pulse stimulation)
• qTBS and iQPS / iqTBS (I-wave-synchronized and individualized QPS/TBS variants)
• AI Mode (AI-driven adaptive stimulation adjusting in real time)
• Custom / programmable burst structures and dynamic pattern generation

Fingerprint TMS™ (concept)
Blossom² is designed to utilize individualized I-wave timing characteristics by delivering advanced stimulation protocols (e.g., iqTBS) synchronized to measured I-wave intervals. The platform enables personalized stimulation research that aligns neuromodulation with intrinsic temporal dynamics of the brain to explore programming neuroplasticity effects.

Caractéristiques / spécifications techniques

• rTMS frequency: up to 100 Hz.
• Paired pulse interstimulus interval S1/S2: ≥ 1 ms (with adjustable intensity jumps).
• Burst rate options: Theta Burst (5 Hz), Alpha Burst (10 Hz), Beta Burst (20 Hz).
• Burst frequency: 10–100 Hz, individually adjustable.
• QPS: sub-millisecond burst timing; quadri-pulse stimulation with adjustable burst timing at 100 μs resolution.
• iQPS / i-wave timing: individualized I-wave intervals with 100 μs resolution.
• QPS bursts maximum burst frequency: up to 1000 Hz for QPS protocols.
• Supports single pulse, paired pulse, rTMS, TBS, alpha/beta burst, QPS, qTBS, iQPS, iqTBS and programmable/custom patterns.
• Features: closed-loop capability, AI-driven adaptive stimulation, fingerprint-guided timing, and unified multi-paradigm platform for neuroplasticity-focused research.