iCARE-2100@ The APTT/PT/TT/FIB Reagent Kit is intended to measure the activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and quantitatively determine fibrinogen (FIB).
Clinically, it is mainly used to screen the intrinsic and extrinsic deficiencies of coagulation system, reflect the content or structure abnormality of plasma fibrinogen and the abnormality in fibrinolytic system. It can also be used for the auxiliary diagnosis of disseminated intravascular coagulation and primary fibrinolysis, monitor the oral anticoagulant treatment, heparin anticoagulant therapy and thrombolytic therapy.
Intended Use
Activated partial thromboplastin time (APTT) is a screening test for the detection of intrinsic coagulation factors. It can be used to detect the deficiencies to the inherited or acquired factors (VIII, IX or XI) or detect the presence of its corresponding inhibitors. APTT can also be used to prove the lacking of coagulation XII, prokallikrein and high molecular weight kallikrein. APTT is the preferred measure of monitoring unfractionated heparin.
Clinically, prothrombin time (PT) is mainly used to screen the extrinsic deficiencies of coagulation system and monitor oral anticoagulant treatment. With prolonged PT, there may be inherited factor II,V,VII,X deficiencies and hypofibrinemia (or afibrinogenemia); The lacking of acquired coagulation factor is found in DIC, primary fibrinolytic hyperactivity, obstructive jaundice and vitamin K deficiency; with shortened PT, there may be inherited factor V excess, oral contraceptives, hypercoagulability and thrombotic diseases.