Applied knowledge in neurology – The TPS® method of action
The key mechanism induced by TPS® is mechanotransduction. The stimulation of growth factors, primarily VEGF3,4, not only improves cerebral blood flow, but also promotes the formation of new blood vessels (angiogenesis) and nerve regeneration. An additional effect is the release of nitric oxide (NO)5, which leads to direct vasodilation and improved blood circulation.
Biological effects of TPS®
Increase in cell permeability7
Stimulation of mechanosensitive ion channels6
Release of nitric oxide (NO)5, which leads to vasodilation, increased metabolic activity and angiogenesis and has an anti-inflammatory effect
Stimulation of vascular growth factors (VEGF)3,4
Stimulation of BDNF8
Migration and differentiation of stem cells4,6
TPS® can stimulate deep cerebral regions, reaching as much as 8 cm into the brain. Owing to the short duration of the TPS® stimulation, tissue heating is avoided. The pulses applied to the treatment area thus develop their maximum clinical effectiveness. TPS® treatment is performed through the closed skull. The patient is not immobilized during the treatment and able to move freely. TPS® treatment has been shown to significantly improve CERAD test performance and to reduce Beck’s depression index in patients with mild to moderate dementia. Over 1500 treatments have already been performed using the NEUROLITH® system.