The Accel-Amplicon Plus Lynch Syndrome Panel is the NGS multigene panel to identify mutations in DNA Mismatch Repair (MMR) genes. It offers comprehensive and exon-level hotspot coverage of 4 clinically-relevant genes: MLH1, MSH2, MSH6 and PMS2. And with sensitivity down to 1% allele frequency, now you can identify both germline and somatic mutations in the same panel.
Comprehensive: Covers 600 COSMIC and 7,500 ClinVar mutations and generates targeted libraries compatible with Illumina® sequencing platforms.
Powerful: Simultaneous detection of single nucleotide variants (SNV) and small insertion and deletions (indels), all within a fast and easy single-tube assay workflow.
Other key features include:
Robust performance on cell-free DNA and FFPE samples starting with as little as 10 ng input.
Highly sensitive detection of rare variants down to 1% allele frequency.
Easy, single-tube assay with sequence ready libraries in 2 hours.
Streamlined analysis with new bioinformatics tools including Primerclip or VarSome.
Compatible with all Illumina sequencers
The Lynch Syndrome Panel offers comprehensive coverage of
4 clinically-relevant Lynch Syndrome genes. The panel covers
over 600 COSMIC and 7,500 ClinVar mutations and generates
targeted libraries compatible with Illumina® sequencing
This panel enables:
• Compatibility with wide range of samples
• Data analysis options including Primerclip
• Addition of your own custom content
Average Amplicon Size 140 bp
Number of Genes 4
Gene List MLH1, MSH2, MSH6, PMS2
Total Target 15 kb
Input Recommended 10 ng amplifiable DNA