The Accel-Amplicon BRCA1, BRCA2, and PALB2 Panel offers comprehensive coverage of the entire coding sequence of the BRCA1 and BRCA2 genes, as well as coverage of all coding exons and 5’ and 3’ UTR regions of PALB2 (partner and localizer of BRCA2). Utilizing 302 amplicons with an average size of 149 bp, this panel generates targeted libraries compatible with Illumina® and Ion Torrent™ sequencing platforms. The unique design of the Accel-Amplicon BRCA1, BRCA2, and PALB2 Panel enables compatibility with FFPE and cfDNA samples. This product is a complete kit that includes all components necessary for generating ready-to-sequence libraries, including primer pairs and indexed sequencing adapters.
This panel is modular, allowing you to add on focused content to achieve your most optimal design. Either use our pre-validated content or add your own targets to the core. We’ll work alongside you to design your assay and then Swift will optimize and wet-bench validate its performance before shipping it to you.
Ready-to-sequence libraries in 2 hours
Inputs as low as 10 ng
Overlapping amplicons for coverage of contiguous regions and whole exons
Average amplicon size of 149 bp for compatibility with FFPE and cfDNA
Limit of detection as low as 1-5% for somatic mutations
On-target specificity and coverage uniformity > 95%
Leverages the high fidelity performance of the Illumina platform
Complete library generation in a single kit
The Accel-Amplicon BRCA1, BRCA2, and PALB2 panel contains
302 amplicons with an average size of 149 bp that covers the
entire coding sequence of BRCA1 and BRCA2 genes,