This thermal cycler offers users excellent flexibility, outstanding throughput, and high performance. Base models are able to be upgraded to gradient capabilities. A vast array of thermal blocks are offered for this device including the Combi-Block (in sizes of 33 x 0.2 ml or 33 x 0.5 ml), the 0.2 ml block (96 x 0.2 ml), the 0.5ml block (60 x 0.5 ml), and also the 384-well block. A color touch-screen and standardized Techne® cycler software make the device user-friendly. Programs can be simply transferred from instruments and temperature logs to a personal computer. The graphical time display operates in real time to provide instant program status visualization. By upgrading the unit using USB devices or by directly using the PrimeG instrument, changing cycling requirements can be managed affordably.