FT-MS spectrometer Orbitrap™ Isora™

isotope ratio massfor researchorbitrap

Short description
Measure isotope and isotopologue ratios directly from intact molecular ions using electrospray ionization and high-resolution accurate-mass detection of the Thermo Scientific™ Orbitrap™ Isora™ Mass Spectrometer.

What is included with purchase

• One Orbitrap™ Isora™ Mass Spectrometer
• Dedicated Thermo Scientific™ Vanquish™ Duo UHPLC system configuration
• Thermo Scientific™ Isotope Discoverer™ Software

Reveal isotope ratios in molecular context
Orbitrap-based isotopologue analysis provides isotope ratio information at the molecular-species level, enabling comprehensive evaluation of isotopic composition across intact molecules and fragments.

Expand your analytical capabilities by analyzing

• Isotope ratios at natural abundance: simultaneous acquisition of major and selected minor isotopologues for high-precision analysis of C, N, O, H and S
• Position-specific isotope ratios: controlled fragmentation to measure isotope ratios from defined functional groups or molecular fragments
• Clumped isotopes: detection and quantification of isotopologues with multiple rare isotope substitutions

Integrated workflow from sample to result
Designed to simplify complex isotope workflows, the Orbitrap™ Isora™ solution supports efficient progression from measurement to evaluated results, even with large, information-rich datasets. Included with purchase:

• Orbitrap™ Isora™ with purpose-built control software for method development and acquisition setup
• Vanquish™ Duo UHPLC System for sample introduction and rapid sample/reference handling to ensure isotopic accuracy
• Isotope Discoverer™ software for integrated data processing, visualization and reporting

Isotope Discoverer software for streamlined data processing
Isotope Discoverer™ centralizes key processing steps to convert high-resolution raw data into final isotope ratio results with improved traceability and throughput.

Key capabilities include

• Extract isotope ratio information directly from high-resolution raw data
• Filter, summarize, and correct data within a structured workflow
• Calibrate results to generate final delta values
• Visualize intermediate and final results for review and troubleshooting
• Export processed data and reports for further analysis and documentation

Product variants (table)
Catalog Number | Model | Max. Resolution
IQLAAMGAATFASMMBQH | Orbitrap Isora Pro Mass Spectrometer | Up to 480,000 at 200 m/z
IQLAAMGAATFASMMBQI | Orbitrap Isora Mass Spectrometer | Up to 240,000 at 200 m/z

Technical specifications

• Dimensions (D x W x H): 30 x 21 x 27.6 in. (763 x 535 x 703 mm)
• Dynamic Range: 5 orders of magnitude intrascan dynamic range
• Fragmentation: Higher Collisional Dissociation (HCD)
• Mass Accuracy: Under defined conditions: External calibration achieves <3 ppm RMS; Internal calibration achieves <1 ppm RMS
• Mass Stability: Under defined conditions: External calibration achieves <3 ppm mass drift over 24 hours; Internal calibration achieves <1 ppm mass drift over 24 hours; EASY-IC (scan-to-scan lock mass correction) achieves <1 ppm mass drift for at least 5 days; 1-point mass calibration achieves <3 ppm mass drift over 4 weeks
• Model: Orbitrap Isora Pro Mass Spectrometer
• Max. Resolution: Up to 480,000 at 200 m/z
• Type: Orbitrap IRMS
• Unit Size: Each