Automation system for the pharmaceutical industry NevoLine™ Upstream

for vaccine development

The NevoLine™ Upstream platform is an innovative biomanufacturing technology that delivers cost-effective viral production. This new generation platform builds on the successful NevoLine™ sIPV  proof-of-concept designed to deliver affordable inactivated polio vaccine. The high-performance, intensified platform features a flexible design to accommodate viral vaccine, gene therapy, and oncolytic virus production. With the NevoLine™ Upstream platform, automated GMP clinical and commercial-scale upstream production is achieved within a 3 m² footprint. Applications Viral vectors Viral vaccines Oncolytic viruses Exosomes Adherent cells Suspension cells Redefining upstream virus production The NevoLine™ Upstream platform accommodates all unit operations from inoculation to clarification and concentration within a compact module. Pre-defined single-use assemblies can be selected and combined to meet your process requirements. FEATURES Integrating the scale-X nitro bioreactor for commercial production The scale-X nitro bioreactor enables commercial-scale production in a compact size while offering 200 m² or 600 m² surface for cell growth. The structured fixed-bed design enables a linear scale-up from the scale-X carbo. As part of the NevoLine Upstream, the bioreactor benefits from the automation and integration offered by the platform. An integrated solution designed for flexibility Compact, ergonomic hardware design Unidirectional air flow cabinet with guided manifolds for simplified connection and operation of single-use assemblies.