Automated molecular screening system

HTSminiature

Overview
Zinsser Analytic provides a fully automated, high-throughput polymorph screening solution that automates the entire workflow from powder dosing and crystallization to analysis‑ready samples. The system is designed to deliver faster results, higher reproducibility, and rapid return on investment compared to manual workflows.

High‑Throughput Solid‑Form Discovery
Polymorph screening is automated end‑to‑end to identify and control solid forms of an API, improving bioavailability, stability, manufacturability, and IP protection. The platform enables walk‑away operation and scales throughput while reducing manual intervention.

Designed for High‑Throughput Polymorph and Salt Screening

• Automated powder handling (optional, mg‑scale)
• Precision liquid and anti‑solvent dosing
• Heating, standard cooling, and low‑temperature (crash) cooling
• Shaking, stirring, evaporation, filtration, and crystallization
• Dynamic experiment loading via Worklist Creator

All process steps are executed on a single integrated robotic platform enabling true walk‑away operation.

End‑to‑End Automated Sample Preparation
The automation covers the entire sample preparation workflow required for polymorph screening:

• Automated dispensing of API powders into reactor blocks
• Automated solvent and anti‑solvent addition
• Precise, programmable temperature control, including low‑temperature crystallization
• Controlled agitation by magnetic stirring or shaking
• Automated evaporation and drying
• Integrated filtration for slurry‑based workflows

This end‑to‑end approach reduces hands‑on time and variability while increasing throughput and data quality.

Crissy® Block Concept — Crystals Ready for Detection
The Crissy® block concept is core to the workflow and is specifically designed to streamline downstream analysis by generating and presenting crystals in an analysis‑ready format for direct X‑ray interrogation.

Key Advantages

• Glass reactor bases positioned approximately 1 mm above the block
• Crystals are directly accessible for X‑ray analysis
• Minimizes sample transfer and form disturbance
• Exchangeable lids allowing automated powder dispensing and solvent access
• Result: crystals generated and presented in an analysis‑ready format with minimal manual intervention

Direct Compatibility with XRPD Systems
Zinsser screening blocks are fully compatible with automated X‑ray diffraction systems for high throughput analysis. Supported/mentioned instrument vendors include Bruker, Malvern/PANalytical, and STOE. Available block formats include 96, 48, and 24 positions. Crissy® blocks and transmission plates are designed for direct loading onto automated XRD stages, eliminating manual sample preparation steps.

Transmission Plates for Advanced XRD Analysis

• Transparent transmission plates for transmission X‑ray measurements
• Crystals are reproducibly transferred into defined cavities (pushed or shaken)
• Ideal for transmission XRD geometries and preserves crystal integrity and spatial distribution

Fully Automated Filtration and Slurry Workflows
The platform integrates:

• Automated filtration blocks
• Positive‑pressure filtration
• Automated transfer of slurries from reactor blocks to filtration blocks
• Filtration blocks directly compatible with XRPD systems for high throughput analysis

These capabilities enable exploration of thermodynamically stable forms under realistic process conditions without manual handling bottlenecks.

True High‑Throughput Robotics — Built for Efficiency
Zinsser HTS polymorph screening systems can feature:

• Multiple robotic arms performing powder handling, liquid handling, gas handling, and transport routines
• Parallel processing of multiple reactor blocks
• Inert operation conditions if required
• Centralized control via WinLISSY® software; experiments can be dynamically queued and executed while the system is running

Fast ROI Compared to Manual Polymorph Screening
Automation benefits include:

• Reduced hands‑on laboratory time
• Improved reproducibility and data consistency
• Lower API consumption through miniaturization
• Faster identification of stable and relevant solid forms
• Earlier, more confident development decisions

Why Zinsser Analytic?

• True end‑to‑end automation (not just crystallization or analysis)
• Optional automated powder handling as a key differentiator
• XRPD‑compatible block designs (Crissy®, transmission plates, filtration plates)
• Extreme temperature flexibility and precise process control
• Open, modular workflow architecture adaptable to evolving screening strategies

caractéristiques / spécifications techniques

• Compatible block formats: 96, 48, 24 positions
• XRPD/XRD compatibility: direct loading onto automated XRD stages
• Core components: Crissy® blocks, transmission plates, filtration plates
• Automated capabilities: powder handling (mg‑scale), liquid/anti‑solvent dosing, evaporation, drying, filtration, transfer, agitation (stirring, shaking), heating and low‑temperature cooling including crash cooling
• Filtration: automated filtration blocks with positive‑pressure filtration and direct XRPD compatibility
• Robotics: multiple robotic arms for parallel processing and transport; inert operation available
• Software: centralized control and dynamic experiment loading via WinLISSY® and Worklist Creator
• Sample presentation: glass reactor bases ~1 mm above block to minimize disturbance; crystals generated in analysis‑ready format
• Throughput scaling: modular design to scale from small screens to high‑throughput campaigns