Fully automated sample preparation system TMA molmed

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Overview
Discover the TMA molmed, a fully automated, high-speed solution for tissue microarray (TMA) creation and molecular sampling from FFPE and mega blocks. Combining precision microarraying with laser microdissection-like functionality, it enables highly accurate tissue extraction for advanced molecular applications in pathology, biobanking and translational research.

Key Features

• Dual-functionality for tissue microarray creation and laser microdissection-like molecular sampling
• Supports standard and mega donor blocks, enabling flexible workflows
• Modular architecture with six configurable core sizes (as small as 0.2 mm)
• Direct molecular sample extraction to PCR tubes or wellplates to avoid cross-contamination
• Digital integration with MRXS digital slides and JPEG overlays for accurate tissue selection
• Comprehensive data management with barcode tracking, automated project saving and multi-format export

Modularity & Sample Processing

• Six configurable core sizes: 0.2 mm (surface), 0.6 mm, 1.0 mm, 1.5 mm, 2.0 mm, 3.0 mm
• Mega block compatibility for high-volume processing
• Configurable layouts: e.g., 6 normal blocks + 1 mega donor + PCR tubes, 3 normal blocks + 1 mega donor + PCR tubes, or 6 normal blocks with PCR
• Open modular design supports PCR cassettes, microtiter plates and customized tissue cassettes

Capacity

• Configurations include combinations of normal donor blocks, mega donor blocks, PCR tubes and wellplates
• Examples: 9 normal blocks (donor or recipient); 6 normal blocks + 1 mega donor block; 6 normal blocks or 1 mega donor block with 3 normal blocks + 30 PCR tubes; 3 normal blocks or 1 mega donor block + 1 wellplate (actual capacity is configuration-dependent)

Core Density / Maximum Cores per TMA Block

• 0.6 mm: up to 558 cores
• 1.0 mm: up to 286 cores
• 1.5 mm: up to 135 cores
• 2.0 mm: up to 84 cores
• 3.0 mm: up to 45 cores

Performance

• Throughput: transfers 200–250 cores per hour
• Supports high-density TMA block creation (see core density values above)
• Automated block height measurement to ensure proper core alignment

Smart Automation & Digital Integration

• MRXS digital slide and JPEG overlay compatibility for precise donor tissue selection
• Barcode tracking and automated donor block imaging
• TMA Control Software for custom recipient block design and real-time project tracking
• Import/export support for common spreadsheet formats for workflow integration

Molecular Workflow Integration

• Direct extraction to PCR tubes or wellplates to minimize contamination
• Support for DNA, RNA and protein extraction enabling downstream PCR, dPCR and sequencing applications
• Multi-format data export (ods, xls, xlsx, csv) for LIMS and downstream analysis

Use Cases

• Molecular pathology and translational research
• Biobanking and large-scale TMA production
• Cancer research, genetics, immunology and infectious disease studies, neuroscience, pharmacology, toxicology and environmental science

Caractéristiques / spécifications techniques

• Denomination commerciale: TMA molmed
• Manufacturer / Brand: 3DHISTECH
• Core diameters (mm): 0.2 (surface), 0.6, 1.0, 1.5, 2.0, 3.0
• Maximum cores per recipient block: 0.6 mm = 558; 1.0 mm = 286; 1.5 mm = 135; 2.0 mm = 84; 3.0 mm = 45
• Throughput: 200–250 cores/hour
• Supported capacities / configurations: multiple, configuration-dependent (examples listed above)
• Barcode reading: 1D and 2D (optional) — Supported 1D codes include Code 39, UPC-A, EAN 13, Codabar, Code 128; Supported 2D codes include Data Matrix, PDF417, QR Code, Aztec, MicroQR
• Supported import formats: .XLS, .XLSX, .ODS
• Supported export formats: .XLS, .XLSX, .ODS, .CSV
• Base unit dimensions (W x D x H): 552 x 400 x 400 mm
• Toolbox dimensions: 310 x 110 x 155 mm
• Power supply unit dimensions: 189 x 90 x 44 mm
• Base unit weight: 29 kg; Toolbox weight: 5 kg; Display weight: 7.1 kg; Power supply unit weight: 0.55 kg
• Camera: 12 MP Blackfly S USB3 digital imaging camera (Sony IMX226), resolution 4000 x 3000 pixels, pixel size 1.85 µm, frame rate 31 FPS, connection USB 3.0
• Light source: Multichannel RGB LED (transmitted light operation)
• Computer system recommended: Processor Intel Core i9-14900 (24 cores, 32 threads) or similar; RAM 64 GB; SSD 256 GB; HDD 2 TB; Graphics output 2x DisplayPort (4096 x 2304); Ports 4x USB 3.2, 2x USB 2.0, 1x Ethernet (10/100/1000); OS Windows 11 Pro (64-bit)
• Accessories included: base molds for paraffin blocks (3 pcs), calibration blocks (normal/mega) 1/1 pcs, punch needles (0.2, 0.6, 1.0, 1.5, 2.0, 3.0 mm — quantities vary by diameter), punch pistons and drills as listed
• Modules available: Drill Module (3 slots), Normal Module (1 slot), Wellplate Module (2 slots), Mega Module (1 slot), PCR Module (1 slot)
• Software: TMA Control Software (layout design, tissue core selection, recipient block design), SlideViewer (digital microscopy), SlideMaster (digital slide converter)