Allergy test kit CMQ0602

diagnosticIgEgenetic

Overview
Allergic reactions, or IgE‑mediated (Type I) hypersensitivity, are rapid immune responses that occur when sensitized individuals are re‑exposed to specific antigens. These responses can produce local or systemic inflammation and physiological dysfunction across respiratory, cutaneous, gastrointestinal and cardiovascular systems. The World Allergy Organization estimates a global prevalence of allergic diseases of 10%–40%.

Common allergic diseases

• Allergic rhinitis
• Allergic asthma
• Atopic dermatitis
• Urticaria
• Food allergies
• Eczema
• In severe cases: anaphylaxis

Clinical features
Clinical presentation varies by allergen, route and level of exposure, patient age and genetic factors. Onset can be immediate (minutes) or delayed; manifestations range from localized symptoms (sneezing, wheeze, pruritus, rash) to systemic reactions such as hypotension and anaphylactic shock in extreme cases. Accurate history and severity assessment are critical for management.

Diagnostic importance
Quantitative measurement of allergen‑specific IgE in serum is essential for confirming sensitization, guiding diagnostic workup and informing treatment decisions. Complementary methods include skin prick testing, component‑resolved diagnostics and correlation with clinical history.

References

• [1] Pawankar R., Canonica G., Holgate S. World Allergy Organization (WAO) white book on allergy, Update. 2013.
• [2] Yunginger JW et al. Quantitative IgE antibody assays in allergic diseases. J Allergy Clin Immunol. 2000 Jun;105(6 Pt 1):1077-84.
• [3] Ahlstedt S. Understanding the usefulness of specific IgE blood tests in allergy. Clin Exp Allergy. 2002 Jan;32(1):11-6.
• [4] Gould HJ, Sutton BJ. IgE in allergy and asthma today. Nat Rev Immunol. 2008 Mar;8(3):205-17.

Technical specifications

• Reaction type: IgE‑mediated (Type I) allergic reactions
• Estimated prevalence worldwide: 10%–40% (World Allergy Organization)
• Common clinical manifestations: allergic rhinitis, allergic asthma, atopic dermatitis, urticaria, food allergies, eczema
• Severe outcome: anaphylactic shock in extreme cases
• Diagnostic emphasis: quantitative detection of allergen‑specific IgE
• Related instruments referenced: AutoLumo S900; AutoLumo A1860; AutoLumo A2000 Plus